![]() Load up Dashboard to see a list of activities per month, each of which is clickable to see a graphical breakdown of the activity. Once data has been uploaded to the TomTom MySports site things are a little slow to navigate, but the amount of data on offer is certainly useful - and it's improved many times over the last few months. The presence of app sync is a crucial step forward for the TomTom Multi-Sport, and all of its sportswatch range, as it mean you can ignore plugging into that cradle every day. The Huawei Mate Ascend 7, on the other hand, didn't want anything to do with the application for whatever reason, citing incompatability at this moment in time. With the Samsung Galaxy Note 4 (screen grab image above) we were happily auto-syncing from TomTom to phone via Bluetooth and then to MySports via a mobile data connection, without us needing to do anything. Or, if you have an iOS or Android phone there's also an auto-sync app to make the process all the easier - although it doesn't work with all devices. Uploading is simple via the USB cradle attachment, with TomTom MySports Connect firing into action thereafter. We're talking weeks of activities rather than just a few days, so on board storage is ample before nothing more can be recorded. ![]() Rarely did we reach a point where the Multi-Sport sportswatch became full of our activities - but it can happen if you don't sync it to TomTom MySports via the downloaded Mac/Windows app or smartphone auto-sync. We've achieved poor, fair, good, excellent or no recovery, accompanied by a smiley or sad face - but seem to get a different recovery each day. However, when left in play for a couple of minutes, this pause screen will calculate your recovery based on heart-rate. The initial pause screen isn't a single button press, which we find a little irritating for quick stopping of activities - every second counts after all. Pocket-Lint Recommendation: Nintendo Switch.Pocket-Lint Recommendations: Xbox Console.Pocket-Lint Recommendation: Google Nest.Pocket-Lint Recommendation: Amazon Echo Devices.Pocket-Lint Recommendations: Fire TV Stick.
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Studies have revealed the specific connection between infection-trigger and disease onset in a cohort of Chronic Fatigue Syndrome patients. The identification of these antibodies and the development of better testing provide hope for more targeted therapies and better treatment outcomes.Ĭhronic Fatigue Syndrome (CFS), a disease characterized by profound fatigue, sleep abnormalities, pain, and other symptoms that are made worse by exertion, is infamous for its confounding etiology. With the vast and vague symptomatology, and no previously known etiology, diagnosis and treatment proved elusive and challenging. ĭoctors compare the level of disability seen in POTS to the quality of life experienced in conditions like Chronic Obstructive Pulmonary Disease (COPD) or congestive heart failure. The work of endocrinology labs have correlated autoantibodies to the beta-adrenergic receptors with Postural Orthostatic Tachycardia Syndrome (POTS). The Heart Rhythm Institute at the University of Oklahoma points to an autoimmune basis in a condition that presents as chronic malfunction of the autonomic nervous system. Postural Orthostatic Tachycardia Syndrome Current research is trying to determine the exact role of these autoantibodies and whether they correlate with the symptomatology of Chagas disease. While the exact pathophysiology of Chagas disease is not completely understood, some models have shown that an overstimulation of the immune system causes production of adrenergic autoantibodies. Refractory Hypertension associated with autoantibodies to beta1-adrenergic receptors has been documented in diabetic patients. ![]() In canine models inoculated with adrenergic autoantibodies, it has been shown that beta blockers can negate certain cardiac arrhythmias. In rabbit models, increased expression of autoantibodies has been directly correlated with induction of atrial fibrillation. Cardiomyopathy due to autoimmune dysregulation and production of autoantibodies has been seen in humans and reproduced in animal models. However, it has been proposed that both beta1-adrenergic receptor polymorphisms and autoantibodies could be working together in the development of chronic heart failure. The combination of these two properties can result in bimodal effects on receptor activity that are meaningful for basal activity and chronotropic catecholamine responses of human cardiomyocytes.” īeta-1 adrenergic receptors are the primary receptor of the heart and, therefore, autoantibodies to these receptors have been tied to many different heart diseases.Īutoantibodies to beta1-adrenergic receptors are linked to chronic heart failure. ![]() “Beta1 autoantibodies trigger conformational changes in the receptor, attenuate receptor internalization. Laboratory models have revealed a mechanism by which adrenergic autoantibodies accomplish their effects on the cardiovascular system. There is compelling evidence that autoimmunity against this class of G protein-coupled receptors results in a variety of pathologies:Ĭirculating autoantibodies to adrenergic receptors have been identified in numerous heart diseases and cardiac symptoms. The implications of high titers of these circulating antibodies are still being worked out and further investigated. heart muscle contraction, smooth muscle relaxation and glycogenolysis. β receptors couple to G s, and increases intracellular cAMP activity, resulting in e.g. α 2, on the other hand, couples to G i, which causes a decrease in neurotransmitter release, as well as a decrease of cAMP activity resulting in smooth muscle contraction. α 1 couples to G q, which results in increased intracellular Ca 2+ and subsequent smooth muscle contraction. ![]() Adrenaline or noradrenaline are receptor ligands to either α 1, α 2 or β-adrenergic receptors. ![]() ![]() In the first speech, it is worth noting that the verbal inscription has become white. The red-white-orange color palette has remained unchanged, while other elements have succumbed to significant updates. The logo was updated by the popular Mexican designer Carlos Villaseñor Musquis. The last to date, the redesign, was completed in 1992. The space between the orange lines was white. At the same time, the lines became smaller the farther from the brand name they were. At the same time, it was decided to add three horizontal orange stripes at the bottom of the inscription. The inscription was on a white background. The key element was the verbal inscription, which remained identical to the original version. The cart image has been removed because, over the years, “Oxxo” has already become synonymous with affordable shopping for many. The original version of the logo lasted only a few years and was later somewhat simplified. As a result, these lines represent a handle that the customer can use to hold the cart. Of particular note are the elongated stripes in both “x”s, one below the other diagonally. All letters are lowercase, which should inspire confidence on the part of buyers. Under the emblem was the name of the store, “Oxxo.” It is made using a classic sans-serif typeface. Immediately after getting acquainted with it, the buyer has an association with shopping since the key element is a grocery cart with products inside. The first version of the logo is presented in red. They are located in small towns and metropolitan areas, including Mexico City. The number of mini-stores continues to grow. Every day, Oxxo stores serve about 50 million people in this country. It is the largest retail chain in Mexico. Therefore, the changes are purely style-related. This was made possible not only by a progressive advertising campaign but also by using a catchy red and white color scheme, which has not changed since the project’s launch. Visual recognition of the brand is at a high level. Moreover, the redesign made only minimal changes related to the location of the elements. These are codes or other offers for Otixo which have previously expired, or which our community of users has voted down over time although they might still be valid.Given that the target audience of the chain of stores is almost every resident of Mexico, the company tried to make an intuitive and memorable logo. You may also encounter offers that are labeled "Expired". Be sure to read any comments associated with such codes before trying to use them. These codes appear with a blue "Community-Submitted" tag. Because of the volume of these user-submitted codes, they are not tested, nor guaranteed to be valid by. Other codes may be submitted by our community of users as with any electronic bulletin board. Codes that appear on as Staff Picks (those stamped with a Staff Pick yellow badge, as opposed to blue Community-Submitted badge) have been provided to us directly by Otixo. Enter the code at checkout to see the updated discount price or free shipping offer if your purchase qualifies. If the offer is associated with a coupon or promotion code, simply click on the code and shop through the page that opens on the Otixo website. The discount or offer will appear upon checkout if your purchase qualifies. If you see an offer on associated with a text link-the offer will say "Click to Redeem", simply click the link and make your purchase through the window that opens on the Otixo web site. Otixo offers discounts and special offers through both text links and banners as well as coupons and promotion codes. ![]() It’s free, but limited in that it only prioritizes items by when they’re due and that’s limited to whole days. It integrates with the Orchestra web app which can also make to do items for people in various groups. It’s voice enabled so you can either speak or type text to do it. If you want to created a to do list for yourself, Orchestra is the app for that. Triple tap to turn it off because it’s gets annoying hearing things like “Screen dimmed” and “Screen locked.” 2. It will also read Tweets (in the Twitter app), emails, and text messages. To start an app, you need to double-tap it, since a single tap just reads what’s tapped. Now, wherever you tap, it will speak what’s there including App names. It might take a couple of tries to get it to work, but you’ll hear “VoiceOver on” when you’ve got it. If you don’t want to look at the phone at all (even out of the corner of your eye), triple-click the home button. If you’re driving or can’t make it out, just tap on the right side of the bubble. Press and hold on the message like you’re going to copy it, but you should have another choice to the right of copy called Speak. Let’s say you can tell you’ve got a text message, but can’t read it for one reason or another. Press the home button and now you can do a couple of things that you couldn’t before. Now go to the bottom of the screen and set Triple-click Home to ToggleVoiceOver. Make sure VoiceOver is off and turn Speak Selection on. To get your phone to read things to you (let’s say you’re in the car or have left your glasses somewhere and you can’t quite make out the text), you need to turn on a couple of accessibility options. Will it read your email or text messages to you? Nope. Just hold down the home button until the voice over screen comes on and say “play music” or “call Tina mobile” and it will do it. Apple’s built-in solutionsīeginning with the iPhone 3Gs, Apple introduced a feature called “voice control.” If you only want to call someone, play audio, or ask your phone what time it is, this is the app for you. It could be that you want one or two of Siri’s features, but don’t need the whole shebang.ĭepending on what you want to do, you might be able to do that for very little money or even free. I’m not against jailbreaking my iPhone 3GS, but it seems that iOS 5 has made that more difficult than in the past, so I’m not going to try to get my phone to pretend to be an iPhone 4S so that I can get Siri (although it’s tempting). There are several ways to do parts of what “she” does, but nothing seems to do it all or do it as well. With this in mind, I started looking for ways to do this for less than buying a new phone.įirst the bad news. My wife is always saying, “Wouldn’t it be nice if you had a smart phone to remind you to do things?” She knows I have an iPhone 3Gs, but I just don’t like typing reminders to myself. That’s such a big draw for me that I’m really tempted by it. I’m not the most organized person in the world, so I really like the idea of having Siri remind me to do things later. I’d like a better camera, but I did just buy a DSLR, so that’s not really a good excuse. ![]() At least that’s what I tell myself every time I’m talking myself out of running to my local Apple store and buying the new iPhone 4S. ![]() ◊ Search Ebay, Amazon, Wolfram Alpha, etc.I wouldn’t say I’m cheap as much as I like not being under contract. ◊ Spell supercalifragilisticexpialidocious Your almost hands-free, eyes-free virtual assistant helps you in all situations: Some examples of the phrases you can say to your phone: We are always enhancing our product so you will be getting great new features in the future to come! With voice actions you will no longer need to memorize special keywords or phrases, simply speak into your smartphone and voice actions will automatically respond to what you need. With voice actions you will be able to send emails, voice dial your contacts, set alarms, reminders, answer questions, listen to music and much more. ![]() Talking personal assistant Jeannie will not only help you get through your day but will also be the only app you’ll need for your smartphone! Get one of the top selling voice assistant apps today that has over 1 million downloads to date!! Microsoft Windows 7 and Ubuntu 18.04 are not supported anymore. SHA-1 : 3097C096EA9679FE7BEF909583568752A6FC262FĬisco Packet Tracer 8.2.1 can be installed on Microsoft Windows 8.1, Microsoft Windows 10, Microsoft Windows 11, Ubuntu 20.04 LTS and MacOS 10.14. This is a major change in Cisco delivery policy for Packet Tracer as previous versions were only available for Netacad students and instructors.įile : CiscoPacketTracer_821_Windows_64bit.exe Self learners are able to download Cisco Packet Tracer after registering on Cisco Netacad website. The main new feature of Packet Tracer 8 x is the addition a new SDN Network Controller allowing emulated network programming through API exposed by Packet Tracer to the host.It is distributed as a debian package (.deb) for Ubuntu 20.04 LTS.Ĭisco Packet Tracer 8.2 is created by Cisco Systems TM and is provided for free to everyone. Packet tracer 8.2 adds a new OSPF comand to the Packet Tracer 8.x serie which added a new Packet Tracer Tutored Activities (PTTA) engine as well as bug fixing and improvements on accessibility, usability, and security. Download Cisco Packet Tracer 8.2.1 Cisco Packet Tracer 8.2.1 release infoĬisco Packet Tracer 8.2 has been released in summer 2022 and is now available for download on Netacad website. This new GNS3 v3.0.0 alpha 3 fixes several GNS3 3.0.0 issues and adds Python 3.11 support to align with GNS3 v2.2. GNS3 v3.0.0 alpha 3 has been released a few days ago on december 27, 2022. Starting with v2.2.37, only macOS 11 and above is supported. ![]() This version fixes broken websocket console with Python 3.11 as well as Qemu binary not set when adding appliance from template. Update : GNS3 v2.2.38 has been released on February 28, 2023. ![]() ![]() Update : Cisco Packet Tracer 8.2 has been released a few days ago for download ! This release introduces a new show ip ospf interface brief command as well as bug fixing regarding incompatible DLLs that caused Packet Tracer crashes. You have a limited (and not expandable) number of weapons and auxiliary equipment slots. Which ship systems should I improve first, how much energy capacity should I upgrade to, and if I find a merchant what should I buy? A player cannot do everything. You are constantly deciding if you should spend your scrap (think money) to improve a specific ship system or hoard the scrap in hopes of running across a store which might have a better weapon or a useful crew member. You can open your doors to outer space to put out fires caused by enemy ship attacks, but your crew will slowly die from a lack of oxygen if you don’t shut the doors and generate more air. If you maximize your shields you may be unable to run your engines to maximum or use all of your weapons systems. The player performs a large number of macro and micro management decisions. The player juggles a limited number of energy points, crew members, and consumables (fuel, missiles, and drone parts) to maximize performance. For example, your engine will be in only one room regardless of how many times you upgrade the engine. (Excepting the boss Rebel ship) both your ship and enemy ships only have one room containing any one type of equipment. Optional equipment includes cloaking devices, teleporters, and a few other odds and ends. Other equipment may be discovered or you lack the room to put it in your ship. Some of the equipment is common to all ships like an oxygen generator, steering controls, engine, door controls, sensors, weapons, and shields. Each individual room may have a piece of equipment. Doors connect the rooms (including a few to outer space). The main screen is a schematic of your ship. You only have a couple of screens to look at. ![]() yes we are having a blast! This game has a huge fun factor coupled with a very simple game design. Die in multiple ways almost simultaneously (run out of weapons and fuel as your ship is consumed with fire as your oxygen expires and your last crewmember is shot down by boarders like a dog).Īre we having fun yet? Well……. See all of your crew killed by enemy boarding parties. Watch your crew die from a lack of oxygen. If your mission succeeds you will navigate through all of the sectors, win your battles, add crew (up to a maximum of eight), add better weapons and equipment and defeat the rebel flagship. To defeat the rebels you must guide your underpowered space ship through a number of star filled sectors defeating other single ships while being slowly chased by a huge enemy fleet. You have information vital to the destruction of the Rebels. You belong to a Federation under attack by Rebels. You command a single space ship with a tiny crew. In Space No One Can Hear Your Ship ExplodeįTL: Faster Than Light is an very simple, inexpensive and fun PC game. Some integrated Intel HD graphics cards have been known to work but are not officially supported.Reviewed by Avery Abernethy, 30 September 2012 Publisher: Subset Games Can a game offering simple mechanics, an absurd plot, and multiple, humiliating fails be any fun? Maybe… Graphics:1280x720 minimum resolution, OpenGL 2.0 Support, and recommended dedicated graphics card with 128 MB of RAM.The constant threat of defeat adds importance and tension to every action. No Second Chances! - Permadeath means when you die, there's no coming back.No two play-throughs will be quite the same. Randomized Galaxy - Each play-through will feature different enemies, events, and results to your decisions.Be the Captain You Want - Hundreds of text based encounters will force you to make tough decisions. ![]() Unique Lifeforms and Technology – Upgrade your ship and unlock new ones with the help of six diverse alien races.Play at Your Own Speed - Pause the game mid-combat to evaluate your strategy and give orders.Complex Strategic Gameplay - Give orders to your crew, manage ship power distribution and choose weapon targets in the heat of battle. ![]() What will you do if a heavy missile barrage shuts down your shields? Reroute all power to the engines in an attempt to escape, power up additional weapons to blow your enemy out of the sky, or take the fight to them with a boarding party? This "spaceship simulation roguelike-like" allows you to take your ship and crew on an adventure through a randomly generated galaxy filled with glory and bitter defeat. It's a dangerous mission, with every encounter presenting a unique challenge with multiple solutions. In FTL you experience the atmosphere of running a spaceship trying to save the galaxy. FTL: Faster than Light Steam Gift Platform: The most Powerful and Simple PDF solution that changes the way you work with your important documents forever. ![]() The easiest way to create, edit, convert and sign PDF documents. To sum things up, Wondershare PDF Editor has all the functions and features of a powerful PDF managing tool that you can certainly use to improve documents or create new ones that fit your needs. - Portable File size: 152.02 MB The PDF Experience, Simplified. 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As far as exporting the document content is concerned, with Wondershare PDF Editor it’s possible to convert the original to DOC, XLS, PPT, BMP, GIF, JPG, PNG, TIFF, ePub, HTML and RTF formats. The PDF format, or Portable Document Format file, was developed by Adobe Systems. You can open and work with multiple files at the same time, extract specific pages and even combine PDF documents. Supported operating systems - Windows 10, 8.1, 8, 7, Vistaġ.The application enables you to open any PDF document and with a few clicks you can add text or access the OCR tool. ![]() Get the flexibility to provision, track, and manage licensing across groups and teams.Ī computer with an Intel Pentium 4, higher, or equivalent processor Work easily with an all-new minimalist, yet powerful, user interface. 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PDFelement is one of the best PDF editors that lets you create and edit PDF files. ![]() Ability to view photos, bookmarks, annotations, and content search. Convert PDF files to other formats such as DOC, XLS, PPT, BMP, GIF, JPG, PNG, TIFF, ePub, and HTML. Download Wondershare PDFelement Pro Portable Wondershare PDFelement Pro 7.6.8 Portable Hng dn cài t và kích hot 1 Tài v, gii nén (Có th dùng Winrar 5. The most Powerful and Simple PDF solution that changes the way you work with your important documents forever.Įxpress yourself both verbally and visually with a full featured word processor that helps you easily edit PDF files.ĭeliver the richest, most engaging PDF communications. Features For Wondershare PDFelement 9.4 Pro Portable Create and edit PDF files. ![]() ![]() Optionally, all other IP addresses and FQDNs are listed as subjectAltName. The CommonName contains a wildcard or exact match for the primary node or FQDN of the virtual IP address.Verify that your custom SSL certificate meets the following requirements.biostar_cert.p12 (newly created PKCS#12(*pfx) or PCKS#12(*p12) biostar_cert.crt (biostar_cert.pem (*pem)chain type) Final result of newly combined/bundled certificates must be as below located in BioStar 2 File → nginx → conf Bundled/Combined certificates name must be >Make a back up file before applying the new combined/bundled certificates click on import key pair → PKCS#12→ import the newly made biostar_cert.p12Ĭaution: Import → Alias name must be biostarĮnter New Password as you desire →Click OkĬaution: File name must be keystore.jks File format must be KeyStoreFiles Open Key Store → Create a new Key Store → JKS → import the original biostar_cert.p12 (incorrect certificate file)Ĭontact your designated SUPREMA TECH SUPPORT or create a new ticket to receive the password for the original bopstar_cert.p12 password Download KeyStore Explorer: create, manage JKS (Java Key Store).Install KeyStore Explorer to combine/bundle newly made certificates correctly Go back to → Certificates → ONLY Click on the lowest stack and export the fileĬaution:File Name Must be biostar_cert_new File Format Must be PKCS#12(*pfx) or PKCS12(*p12) After checking the validity of the cert.key → Go back to Private Key → Export the key, this newly made cert.key will be the new key for the newly bundled certificates Caution : File Name must be biostar_cert_key, File Format must be PEM.private(*pem) check the avialibty of the private key ![]() Their relationship is quite groundbreaking because they’re an interracial couple (which we don’t see enough of) and it’s rare we see such a heavy topic addressed in a show so mainstream. In the penultimate episode of the first season, the two got tested for STDS, and it’s eventually revealed that Oliver is HIV positive. The former had a reputation for being a playboy, but renounced his ways after he met Oliver, who also helped him through his drug addiction. Connor Walsh and Oliver Hampton (Jack Falahee and Conrad Wayne Ricamora) – How to Get Away with MurderĬonnor and Oliver have had an on-and-off relationship since the start of the series. Her relationship with Arizona Robbins was also lauded by critics, and the two became firm fan-favourites within the LGBTQ community, being frequently named as two of the most iconic lesbian characters on television. After appearing in in 11 seasons and 239 episodes, Callie became the longest running LGBTQ character in TV history. Can we get an amen up in here? Callie Torres and Arizona Robbins (Sara Ramirez and Jessica Capshaw) – Grey’s Anatomyīisexual character Callie Torres has received universal acclaim ever since her introduction to Grey’s Anatomy in the show’s third season. Blanca is a true queen in all senses of the meaning. Mother of the House of Evangelista, she keeps her queer brood in check with a firm, fair and fabulous heart, making sure they all have the love and support to achieve the opportunities she never had herself. She may have only strutted onto our television screens very recently in Ryan Murphy’s groundbreaking series Pose, but she is well on her way to iconique status in our eyes. When it comes to Blanca Evangelista it’s 10s across the board from us. The Pierce family does a great job of doing that.” Blanca Evangelista (M.J. I hope that our family on the show is an inspiration for some families just to be open and accept your children and love them. My hope is that when you watch Anissa, a young lesbian is inspired to walk boldly as who she is and to love herself and to love herself exactly how she looks. ![]() ![]() I’m just really grateful to tell the story for young lesbians – and black lesbians in particular – who don’t really see themselves on TV. Nafessa Williams’ portrayal as Anissa Pierce has been lauded for making television history as the first black lesbian superhero. In an interview with Entertainment Weekly, Nafessa said: “I believe love is love. Anissa Pierce (Nafessa Williams) – Black Lightning The show was cancelled earlier this year, breaking the hearts of millions of fans who ‘ship’ the couple, which has been described as one of the most natural and realistic LGBTQ romances on air. Throughout the show’s run, Malec have received three Teen Choice Award nominations, while Matthew Daddario (Alec) has won two for Breakout Star and Sci-Fi/Fantasy Actor. Alec Lightwood and Magnus Bane (Matthew Daddario and Harry Shum Jr) – Shadowhuntersĭubbed ‘Malec’ by the fans, this Shadowhunters romance has become one of the most championed TV relationships in recent memory, spawning thousands of (mostly erotic) fan fiction across Tumblr. To celebrate this milestone in queer visibility, we looked back over the past three decades and rounded up the 30 most iconic LGBTQ characters in TV history, from loveable gay couple Mitchell and Cameron to trans trailblazers like Sophia Burset. Over the past decade, representation for the LGBTQ community on television has vastly improved.Ī recent report from GLAAD found that the amount of queer characters on our screens has increased by over 100 to a new record, helped by Ryan Murphy’s acclaimed series Pose which featured the largest cast of LGBTQ actors in a scripted drama. Did your favourite screen queen make the list? ![]() To maintain & improve a positive awareness, the Association will address critical issues that are a concern to the membership & the public. The Southwest Riverside County Association of REALTORS ® will continue to support the consumer’s need for REALTORS ® in the real estate industry. We support the preservation of the right to own, transfer and use real property through legislative advocacy and community involvement. First, the agent sharing his or her account must give. MATRIX is a world-class, award-winning learning management system (LMS) for businesses. ![]() The purpose of the Southwest Riverside County Association of REALTORS ® is to enhance the ability and opportunity of its members to conduct their businesses successfully, ethically and professionally. In the Matrix system, teams are used to allow MLS users access to the accounts of other users. Provide easy access to lenders, insurers, and contractors, including your recommendations, to help your clients understand their choices.Mission Statement of the Southwest Riverside County Association of REALTORS® Our help desk is available via phone or online and manned by long term local staff. Join our distinguished group of real estate professionals and get access to the tools, resources, and networking opportunities you need. ![]() Manage OneHome Marketplace Recommendations. We have the largest number of MLS staff in Ohio ready to serve you.You can also monitor a client’s PropertyFit preferences and see how preferences change over time. ![]() Using the Matrix Contact Manager, you can track your client’s progress in the buying or selling process from start to finish.
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